氯苯那敏 目录 合成機制 適應症及用量 不良反應 參見 外部連結 导航菜单132-22-9AB0427251210APRD00001DB0111426243U6IO1965UD07398CHEBI:52010CHEMBL505美國專利 2,567,245美國專利 2,676,964MedlinePlus Drug Information: Chlorpheniramine编编编
BromazineBromazineCarbinoxamineCarbinoxamineClemastineClemastineChlorphenoxamineChlorphenoxamineDiphenylpyralineDiphenylpyraline苯海拉明DoxylamineDoxylamineOrphenadrineOrphenadrinePhenyltoloxaminePhenyltoloxamineChloropyramineChloropyramineHistapyrrodineHistapyrrodineMepyramineMepyramineMethapyrileneMethapyrileneTripelennamineTripelennamineBuclizineBuclizine盐酸西替利嗪ChlorcyclizineChlorcyclizineCinnarizineCinnarizineCyclizineCyclizine羟嗪鹽酸左西替利嗪MeclizineMeclizineNiaprazineNiaprazineOxatomideOxatomideBamipineBamipineChloropyramineChloropyramineChlorphenoxamineChlorphenoxamineClemastineClemastineDimetindeneDimetindene苯海拉明IsothipendylIsothipendylMepyramineMepyramine鹽酸異丙嗪ThenalidineThenalidine2-Pyridylethylamine2-PyridylethylamineBetahistineBetahistine組織胺HTMTHistamine trifluoromethyl toluidideUR-AK49UR-AK494-甲基苯海拉明AlimemazineAlimemazineAntazolineAntazolineAzatadineAzatadineBamipineBamipineBenzatropine/BenztropineBenzatropineBepotastineBepotastineBromazineBromazine溴苯那敏BuclizineBuclizineCaptodiameCaptodiameCarbinoxamineCarbinoxamineChlorcyclizineChlorcyclizineChloropyramineChloropyramineChlorothenChlorothen氯苯那敏ChlorphenoxamineChlorphenoxamineCinnarizineCinnarizineClemastineClemastineClobenzepamClobenzepamClocinizineClocinizineCyclizineCyclizineCyproheptadineCyproheptadineDacemazineDacemazineDeptropineDeptropineDexbrompheniramine右溴苯那敏Dexchlorpheniramine右氯苯那敏DimenhydrinateDimenhydrinateDimetindeneDimetindene苯海拉明DiphenylpyralineDiphenylpyralineDoxylamineDoxylamineEmbramineEmbramineEtodroxizineEtodroxizineEtybenzatropine/EthylbenztropineEtybenzatropineEtymemazineEtymemazine氟桂利嗪HistapyrrodineHistapyrrodineHomochlorcyclizineHomochlorcyclizineHydroxyethylpromethazineHydroxyethylpromethazine羟嗪IsopromethazineIsopromethazineIsothipendylIsothipendylMeclozineMeclozineMepyramine/PyrilamineMepyramineMequitazineMequitazineMethafuryleneMethafuryleneMethapyrileneMethapyrileneMethdilazineMethdilazineMoxastineMoxastineNiaprazineNiaprazineOrphenadrineOrphenadrineOxatomideOxatomideOxomemazineOxomemazinePhenindaminePhenindamine非尼拉敏PhenyltoloxaminePhenyltoloxaminePimethixenePimethixenePiperoxanPiperoxanPipoxizinePipoxizine鹽酸異丙嗪PropiomazinePropiomazinePyrrobutaminePyrrobutamineTalastineTalastineThenalidineThenalidineThenyldiamineThenyldiamineThiazinamiumThiazinamiumThonzylamineThonzylamineTolpropamineTolpropamineTripelennamineTripelennamineTriprolidineTriprolidine阿伐斯汀Acrivastine阿利斯汀阿司咪唑Astemizole氮卓斯汀AzelastineBamirastineBarmastineBepiastineBepotastineBepotastineBilastineBilastineCabastinenCarebastine盐酸西替利嗪ClemastineClemastineClemizoleClemizoleClobenztropineClobenztropineDorastine依巴斯汀依美斯汀依匹斯汀Epinastine氟卓斯汀KetotifenKetotifenLatrepirdineLatrepirdineLevocabastineLevocabastineLinetastine氯雷他定MapinastineMebhydrolinMebhydrolinMizolastineMizolastineMoxastineMoxastineNoberastineOctastine奥洛他定PerastinePiclopastineRocastineRupatadineRupatadineSetastineSetastineTalastineTalastineTemelastineTerfenadineTerfenadineZepastine地氯雷他定非索非那定鹽酸左西替利嗪BelarizineEfletirizineElbanizineFlotrenizineMedrylamineMedrylamineNapactadinePibaxizineTagorizineTrelnarizineTrenizineVapitadine三环类抗抑郁药阿米替林doxepindoxepintrimipraminetrimipramine四环类抗抑郁药米塞林米氮平Typical antipsychoticTypical antipsychotic氯丙嗪thioridazinethioridazineAtypical antipsychoticAtypical antipsychoticclozapine奥氮平喹硫平AmthamineAmthamineBetazoleBetazoleDimapritDimaprit組織胺HTMTHistamine trifluoromethyl toluidideImpromidineImpromidineUR-AK49UR-AK49BisfentidineBurimamideBurimamide西咪替丁DalcotidineDonetidineEbrotidineEbrotidineEtintidine法莫替丁LafutidineLafutidineLamtidineLavoltidine/LoxtidineLavoltidineLupitidineLupitidineMetiamideMetiamideMifentidineNiperotidineNiperotidineNizatidineOsutidineOxmetidineOxmetidinePibutidineQuisultazine/QuisultidineRamixotidine雷尼替丁RoxatidineRoxatidineSufotidineSufotidineTiotidineTuvatidineVenritidineXaltidineα-Methylhistaminealpha-MethylhistamineCipralisantCipralisant組織胺ImetitImetitImmepipImmepipImmethridineImmethridineMethimepipMethimepipProxyfanProxyfanA-349,821A-349,821A-423,579A-423,579ABT-239ABT-239BetahistineBetahistineBurimamideBurimamideCiproxifanCiproxifanClobenpropitClobenpropitConessineConessineGSK-189,254GSK-189,254ImpentamineImpentamineIodophenpropitIodophenpropitJNJ-5,207,852JNJ-5207852MK-0249NNC-38-1,049NNC 38-1049PF-03654746PF-03654746PitolisantPitolisantSCH-79,687SCH-79687ThioperamideThioperamideVUF-5,681VUF-56814-Methylhistamine4-Methylhistamine組織胺VUF-8,430VUF-8430JNJ-7,777,120JNJ-7777120ThioperamideThioperamideVUF-6,002VUF-6002儿茶素MeciadanolMeciadanolNaringeninNaringeninTritoqualineTritoqualineAmodiaquineAmodiaquine苯海拉明HarmalineHarmalineMetoprineQuinacrineQuinacrineSKF-91,488TacrineTacrineAminoguanidineAminoguanidineAL-LADAL-LADALD-52ALD-52BU-LADBU-LADCYP-LADCYP-LADIP-LADIP-LADDiallyllysergamideDiallyllysergamideDimethyllysergamideDimethyllysergamide麦角新碱ETH-LADETH-LADLAE-32LAE-32LPD-824LPD-824LSAErgineLSDLSD-PipLSD-PipLSHLysergic acid hydroxyethylamideLSM-775LSM-775Lysergic acid 2-butyl amideLysergic acid 2-butyl amideLSZLysergic acid 2,4-dimethylazetidideLysergic acid 3-pentyl amideLysergic acid 3-pentyl amideMethylergometrineMethylergometrineMethylisopropyllysergamideMethylisopropyllysergamideMethysergideMethysergideN1-Methyl-lysergic acid diethylamideN1-Methyl-lysergic acid diethylamidePARGY-LADPARGY-LADPRO-LADPRO-LADAlephAleph (psychedelic)2-Methyl-MDA2-Methyl-MDA2C-B2C-B-Dragonfly2C-B-Dragonfly2C-B-FLY2C-B-FLYβk-2C-Bβk-2C-B2C-C2C-C2C-C-FLY2C-C-FLY25C-NBOMe25C-NBOMe25CN-NBOH25CN-NBOH25CN-NBOMe25CN-NBOMe25D-NBOMe25D-NBOMe2C-D2C-D2C-D-FLY2C-D-FLY2C-E2C-E2C-E-FLY2C-E-FLY2C-E-NBOMe2C-E-NBOMe2C-EF2C-EF2C-F2C-F2C-F-NBOMe2C-F-NBOMe2C-G2C-G2C-G-NBOMe2C-G-NBOMe2C-H-NBOMe2C-H-NBOMe2C-I2C-I2C-I-FLY2C-I-FLY2C-N2C-N25N-NBOMe25N-NBOMe2C-O2C-O2C-O-42C-O-42C-P2C-P2C-T2C-T2C-T-22C-T-22C-T-42C-T-42C-T-4-NBOMe2C-T-4-NBOMe2C-T-72C-T-72C-T-7-FLY2C-T-7-FLY2C-T-7-NBOH2C-T-7-NBOH2C-T-82C-T-82C-T-132C-T-132C-T-152C-T-152C-T-172C-T-172C-T-192C-T-192C-T-212C-T-212C-TFM2C-TFM25TFM-NBOMe25TFM-NBOMe2C-YN2C-YN2CBCB-NBOMe2CBCB-NBOMe2CBFly-NBOMe2CBFly-NBOMe2CD-5EtO2CD-5EtO25B-NBOMe25B-NBOMe25C-NBOH25C-NBOH25I-NBMD25I-NBMD25I-NBOH25I-NBOH25I-NBOMe25I-NBOMe2C-P-NBOMe2C-P-NBOMe3C-AL3C-AL3C-E3C-E3C-P3C-P5-APB5-APB5-APDB5-APDB5-APDI5-APDI5-Methyl-MDA5-Methyl-MDA6-APB6-APB6-APDB6-APDB6-Methyl-MDA6-Methyl-MDABr-DFLYBromo-DragonFLYDESOXYDESOXYDMMDADMMDADMMDA-22,3-Dimethoxy-4,5-methylenedioxyamphetamineDOBDOB-FLYDOB-FLYDOC2,5-Dimethoxy-4-chloroamphetamineDOEF2,5-Dimethoxy-4-(2-fluoroethyl)amphetamineDOET2,5-Dimethoxy-4-ethylamphetamineDOF2,5-Dimethoxy-4-fluoroamphetamineDOI2,5-Dimethoxy-4-iodoamphetamineDOM2,5-Dimethoxy-4-methylamphetamineDOM-FLYDOM-FLYDON2,5-Dimethoxy-4-nitroamphetamineDOPR2,5-Dimethoxy-4-propylamphetamineDOTFM2,5-Dimethoxy-4-trifluoromethylamphetamineEscalineEscalineGanesha (psychedelic)HOT-2HOT-2HOT-7HOT-7HOT-17HOT-17IsoproscalineIsoproscalineJimscalineJimscalineJuncosamineJuncosamineLophophineLophophineMacromerineMacromerineMDA3,4-MethylenedioxyamphetamineMDEAMethylenedioxyethylamphetamineMDMA麦司卡林MethallylescalineMethallylescalineMMA3-Methoxy-4-methylamphetamineMMDA (drug)MMDAMMDA-2MMDA-2MMDA-3aMMDA-3aMMDMANBOMe-mescalineNBOMe-mescalineProscalineProscalineTCB-2TCB-2TFMFlyTFMFlyTMATrimethoxyamphetaminepara-FluorophenylpiperazinepFPPTrifluoromethylphenylpiperazineTMFPPmeta-ChlorophenylpiperazinemCPP1-Methyl-5-methoxy-diisopropyltryptamine1-Methyl-5-methoxy-diisopropyltryptamine2,N,N-TMT2,N,N-TMT4,5-DHP-AMTAL-37350A4,5-DHP-DMT1-(2-Dimethylaminoethyl)dihydropyrano(3,2-e)indole4-Acetoxy-DALT4-AcO-DALT4-Acetoxy-DET4-Acetoxy-DET4-Acetoxy-DiPT4-Acetoxy-DiPT4-Acetoxy-DMTO-Acetylpsilocin4-Acetoxy-DPT4-Acetoxy-DPT4-AcO-MiPT4-HO-5-MeO-DMT4-Hydroxy-5-methoxydimethyltryptamine4-HO-DBT4-HO-DBT4-HO-DPT4-HO-DPT4-HO-MET4-HO-MET4-HO-MPMI4-HO-MPMI4-HO-MPT4-HO-MPT4,N,N-TMT4,N,N-TMT4-Propionyloxy-DMT4-Propionyloxy-DMT5,6-diBr-DMT5,6-diBr-DMT5-AcO-DMT5-AcO-DMT5-Bromo-DMT5-Bromo-DMT5-Me-MIPT5,N-Dimethyl-N-isopropyltryptamine5-MeO-2,N,N-TMT5-MeO-2-TMT5-MeO-4,N,N-TMT5-MeO-4,N,N-TMT5-MeO-α,N,N-TMT5-MeO-α,N,N-TMT5-MeO-α-ET5-MeO-AET5-MeO-α-MT5-MeO-aMT5-MeO-DALT5-MeO-DALT5-MeO-DET5-MeO-DET5-Methoxy-diisopropyltryptamine5-MeO-DiPT5-甲氧基二甲基色胺5-MeO-DPT5-MeO-DPT5-MeO-EiPT5-MeO-EiPT5-MeO-MET5-MeO-MET5-MeO-MiPT5-MeO-MiPT5-MeO-MPMI5-MeO-MPMI5,N,N-TMT5-N,N-TMT7,N,N-TMT7,N,N-TMTα-ETalpha-Ethyltryptamineα-MTalpha-Methyltryptamineα,N,N-TMTAlpha-N,N-TrimethyltryptamineAeruginascinAeruginascinBaeocystinBaeocystin蟾毒色胺DALTDBTDibutyltryptamineDCPTDicyclopropyltryptamineDETDiethyltryptamineDIPTDiisopropyltryptamineDMTDPTDipropyltryptamineEiPTEthylisopropyltryptamine4-羟二乙基色胺4-磷酸二乙基色胺4-羟二异丙基色胺METMiprocinMiPTNorbaeocystinPiPT脱磷酸裸盖菇素裸盖菇素AL-38022AElemicinIbogaineMyristicinNoribogaineVoacangine二苯乙醇酸-3-喹咛环酯阿托品BenactyzineBenzatropineBenzydamine百比停BRN-1484501溴苯那敏CAR-226,086CAR-301,060CAR-302,196CAR-302,282CAR-302,368CAR-302,537CAR-302,668Chloropyramine氯苯那敏ClemastineCS-27349CyclizineCyproheptadineDicycloverineDimenhydrinate苯海拉明DitranDoxylamineEA-3167EA-3443EA-3580EA-3834Flavoxate天仙子胺MeclozineMepyramineN-Ethyl-3-piperidyl benzilateN-Methyl-3-piperidyl benzilateOrphenadrineOxybutynin非尼拉敏PhenyltoloxamineProcyclidine鹽酸異丙嗪東莨菪鹼Tolterodine苯海索TripelennamineTriprolidineWIN-2299
世界卫生组织基本药物吡啶有机氯化合物H1受体拮抗剂血清素-去甲肾上腺素重摄取抑制剂
藥物组胺H1受体拮抗剂抗組織胺藥化学式過敏性鼻炎荨麻疹
维基百科中的醫療相关内容仅供参考，詳見醫學聲明。如需专业意见请咨询专业人士。body.skin-minerva .mw-parser-output table.infobox captiontext-align:center
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| 系统（IUPAC）命名名称 | |
|---|---|
3-（4-氯苯基）-N，N-二甲基 -3- 吡啶-2-基 - 丙烷-1-胺基 ： 3-(4-chlorophenyl)-N,N-dimethyl- 3-pyridin-2-yl-propan-1-amine | |
| 临床数据 | |
| 妊娠分级 |
|
| 给药途径 | 口服、靜脈注射、肌肉注射、皮下注射 |
| 合法狀態 | |
| 合法状态 |
|
药代动力学数据 | |
| 生物利用度 | 25－50% |
| 蛋白结合度 | 72% |
| 代谢 | 肝（CYP2D6） |
| 生物半衰期 | 21－27小時 |
| 排泄 | 腎 |
| 识别信息 | |
| CAS注册号 | 132-22-9  |
| ATC代码 | R06AB04 |
| PubChem | CID 2725 |
| IUPHAR/BPS | 1210 |
| DrugBank | APRD00001 DB01114 |
| ChemSpider | 2624  |
| UNII | 3U6IO1965U |
| KEGG | D07398 |
| ChEBI | CHEBI:52010 |
| ChEMBL | CHEMBL505 |
| 化学信息 | |
| 化学式 | C16H19ClN2 |
| 摩尔质量 | 274.788 g/mol |
| 物理性质 | |
| 水溶液 | 5.5 mg/mL (20 °C) |
氯苯那敏（Chlorpheniramine），又稱扑尔敏，是用在預防過敏性疾病如鼻炎和蕁麻疹症狀中使用的第一代烷基胺抗組胺藥。相比於其他第一代抗組胺藥其鎮靜作用較弱。氯苯那敏是在獸醫，小動物中最常用的抗組胺劑之一。雖然通常不作為抗抑鬱藥或抗焦慮藥，氯苯那敏似乎具有這些特性，是一種用於過敏症狀的藥物，屬於第一代组胺H1受体拮抗剂（又稱抗組織胺藥），化学式C16H19N2Cl。生產藥品時，通常使用其鹽類馬來酸氯苯那敏（Chlorpheniramine maleate）。
目录
1 合成機制
1.1 方法一
1.2 方法二
2 適應症及用量
3 不良反應
4 參見
5 外部連結
合成機制
方法一
氯苯那敏合成機制1：D. Papa, E. Schwenk, N. Sperber, 美國專利 2,567,245 (1951)
方法二
氯苯那敏合成機制2：由吡啶由4-氯芐基氯烷基化合成、D. Papa, E. Schwenk, N. Sperber, 美國專利 2,676,964 (1954)
適應症及用量
減輕過敏症狀，例如過敏性鼻炎（包括花粉症）、荨麻疹等。氯苯那敏可減輕流鼻涕及噴嚏。用於口服時，成人劑量通常是每4至6小時服4毫克。
不良反應
主要是容易令人產生睡意，其它比較常見的不良反應有頭痛、小便滯留、口乾、腸胃不適等。
參見
- 苯海拉明
- 右美沙芬
鹽酸吡甲胺（Tripelennamine）
鹽酸萘甲唑啉（Naphazoline/Naphazoline hydrochloride）
氯化苄乙氧铵（芐索氯銨/Benzethonium chloride）
對羥基苯甲酸甲酯（Methylparaben/Methyl parahydroxybenzoate）
外部連結
- MedlinePlus Drug Information: Chlorpheniramine
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